can a new antiseptic agent reduce the bacterial colonization rate of central venous lines in post- cardiac surgery patients?

background: central venous (cv) catheters play an essential role in the management of critically ill patients in the intensive care unit (icu). cv lines are, however, allied to catheter-associated blood stream infections. bacterial colonization of cv lines is deemed the main cause of catheter-associated infection. the purpose of our study was to compare bacterial colony counts in the catheter site before cv line insertion in two groups of post-cardiac surgery patients: a group receiving sanosil (an antiseptic agent composed of h2 o2 and silver) and a control group. methods: this interventional prospective double-blinded clinical trial recruited the patients in three post-cardiac surgeryicus of a heart center. the participants were divided into interventional (113 patients) and control (136 patients) groups. sanosil was added to the routine preparation procedure (chlorhexidine bath one day before and scrub with povidone-iodine just before the cv line insertion). after the removal of the cv lines, the catheters tips were sent for culture and evaluation of colony counts. results: catheter colonization occurred in 55 (22.1%) patients: 26 (23%) patients in the sanosil group and 29 (21.3%) in the control group; there was no significant statistical difference between the two groups (p value = 0.75, rr = 1.05, 95%ci:0.76-1.45). the most common organism having colonized in the cultures of the catheter tips was staphylococcus epidermis:20 cases in the control group and 16 cases in the intervention group. conclusion: catheter colonization frequently occurs in post-cardiac surgery patients. however, our results did not indicate the effectiveness of adding sanosil to the routine preparation procedure with respect to reducing catheter bacterial colonization.